Table 2.
Population metrics: patients with Aortic Stenosis (AS) in internal and external validation cohorts.
| Aortic Stenosisa | Normalb | p | Aortic Stenosisa | Normalb | p | |
|---|---|---|---|---|---|---|
| Internal testing cohort | External validation cohort | |||||
| Patients | 8883 | 111,681 | 516 | 7595 | ||
| Echo-ECG pairs | 67,740 | 517,358 | 2360 | 29,880 | ||
| Age | 78.4 (78.3–78.4) | 65.4 (65.3–65.4) | 0 | 78.9 (78.5–79.3) | 70.4 (70.2–70.6) | 5.6 ×10−195 |
| Gender n (%) | 3.3 ×10−15 | 0.11 | ||||
| Male | 4610 (51.9%) | 59,446 (53.23%) | 283 (54.84) | 3866 (50.9) | ||
| Female | 4273 (48.1%) | 52,235 (46.77%) | 233 (45.16) | 3729 (49.1) | ||
| Race n (%) | 0 | 5.0 ×10−24 | ||||
| American Indian | 68 (0.77%) | 1192 (1.07%) | – | – | ||
| Asian | 136 (1.53%) | 2755 (2.47%) | – | 23 (0.3%) | ||
| Black | 431 (4.85%) | 9807 (8.78%) | 53 (10.27%) | 1177 (15.5%) | ||
| Hispanic | 516 (5.81%) | 7732 (6.92%) | – | 128 (1.69%) | ||
| Other | 721 (8.12%) | 11,927 (10.68%) | 155 (30.04%) | 2291 (30.16%) | ||
| Pacific Islander | 11 (0.12%) | 140 (0.13%) | – | – | ||
| Unknown | 3551 (39.98%) | 48,393 (43.33%) | 141 (27.33%) | 2282 (30.05%) | ||
| White | 3449 (38.83%) | 29,735 (26.62%) | 157 (30.43%) | 1691 (22.26%) | ||
| Ventricular Rate | 76.6 (76.3–77.0) | 78.8 (78.7–78.9) | 0 | 78.9 (77.3–80.4) | 80.8 (80.3–81.2) | 7.2 ×10−13 |
| Atrial Rate | 91.8 (90.5–93.1) | 86.9 (86.6–87.2) | 0.056 | 87.2 (83.3–91.2) | 89.7 (88.6–90.8) | 0.26 |
| PR Interval | 177.9 (177.1–178.8) | 164.5 (164.2 –164.8) | 8.3 ×10−99 | 179.9 (176.3–183.5) | 167.9 (167.1–168.7) | 1.0 ×10−88 |
| QTc Interval | 460.3 (457.4–463.3) | 449.4 (449.2–449.6) | 8.6 ×10−110 | 465.2 (461.6–468.8) | 455.8 (454.9–456.7) | 2.03 ×10−14 |
p-values generated using ANOVA for continuous variables and Chi-square test for categorical variables.
aAortic Stenosis: Moderate to severe AS, Severe AS.
bNormal: No AS, Mild/Borderline/Trace AS, Moderate AS.