Skip to main content
. 2023 Feb 14;14:834. doi: 10.1038/s41467-023-36479-z

Table 1.

Fungal QTL and the identified candidate genes

RDP (UNITE)/OTU ID Taxonomic name Taxonomic rank Chromosome SNP LOD START (BP) END (BP) DIFF (Mb) %h2 (LOD) %h2 (Sex) %h2 (Gen) %h2 (Diet) %h2 (Cage) ρ (Sex) ρ (Gen) ρ (Diet) Model Candidate genes
2 Basidiomycota Phylum 7 UNC12630138 10.35 36217417 36377617 0.1602 10.8 0.2 2 0.79 35.85 0.0672 −0.0234 0.0718 IntDiet Gm23292
2 Basidiomycota Phylum 11 UNC20492040 9.07 117545132 118530429 0.985297 9.53 0.2 2 0.79 35.85 0.0672 −0.0234 0.0718 IntDiet Tmc8,6030468B19Rik,Gm20708,Tha1,Dnah17,Usp36,Tnrc6c, Tmc6,Tk1,Afmid, Bircs, Tmem235, Socs3,Pgs1,Rbfox3,Syngr2,Cyth1,Timp2,Cep295nl, Lgals3bp, Cant1, C1qtnf1,Engase
1616 Zygomycota;Incertae_sedis_10 Class 7 UNC13835983 11.19 129034744 130149978 1.115234 11.63 0.1 2.12 0.53 1.21 0.1847 −0.0781 0.034 IntDiet Plpp4 Wdr11
112 Polyporales Order 6 UNC12042546 10.37 126848048 127850668 1.00262 10.82 0.13 0.31 0.93 15.06 0.0446 −0.0563 0.0313 IntDiet Akap3,Rad51ap1,Cracr2a,Ndufa9,Dyrk4,D6wsu163e,Fgf6,Fgf23,Tigar,Parp11,Prmt8
40 Russulales Order 9 UNC16882054 11.7 93022854 94468212 1.445358 12.12 0.08 4.08 0.48 9.95 0.0365 −0.0689 0.0062 IntDiet Gm24200
121 Cantharellales Order 18 JAX00081898 9.39 31199252 32034289 0.835037 9.85 <0.01 0.75 0.23 5.22 0.123 −0.0493 −0.0058 IntDiet Myo7b,Rit2,Syt4,Slc25a46,Sap130,Ammecr1,Polr2d,Wdr33,Sft2d3,Lim52,Gpr17
2156 Hypocreales_unidentified Family 13 UNC22815472 9.97 70348004 71076189 0.728185 10.43 0.01 3.32 0.1 13.54 0.1903 −0.0743 0.0194 IntDiet Ice1,Adamts16
2314 Corticiaceae Family 18 UNC28777523 13.46 14637698 15762396 1.124698 13.81 0.07 0.94 0.45 5.92 0.1452 −0.0942 −0.1013 IntDiet Psma8,Ss18, Taf4b, Kctd1,Aqp4,Chst9
2157 Hypocreales_unidentified_1 Genus 13 UNC22815472 8.86 70693059 70712481 0.019422 9.32 <0.01 3.43 0.11 13.64 0.1893 −0.0736 0.0203 IntDiet Gm36607
5603 Vuilleminia Genus 18 UNC28777036 9.63 14637698 16134939 1.497241 10.09 0.13 1.23 0.06 4.33 0.1743 −0.1016 −0.0759 IntDiet Psma8,Ss18, Taf4b, Kctd1,Aqp4,Chst9
1758 Geosmithia Genus X UNC31499614 10.76 153533292 158259643 4.726351 11.2 0.02 1.15 0.08 13.96 0.2821 −0.2599 0.0715 IntDiet Cypt3,Samt4,Magea6,Kctd12b, Nbdy, Spin2c,Samt1,Samt2,Cldn34b1, Cldn34b2,Magea8,Magea1, Magea2, Magea5, Sat1, Acot9,Prdx4, Ptchd1,Phex, Sms, Klhl34, Cnksr2,Yy2,Mbtps2,Smpx
OTU2352 Penicillium citreonigrum Species 1 CEAJAX00009745 11.7 133222151 133859717 0.637566 11.86 0.01 7.31 0.23 19.14 0.0075 −0.1375 −0.0268 IntDiet Kiss1,Snrpe,Zc3h11a,Atp2b4,Plekha6, Golt1a,Gm28040,Etnk2,Sox13,Gm38394,Zbed6,Lax1
OTU29 Malassezia restricta Species 8 UNC080619407 8.77 22671231 23905921 1.23469 9.03 <0.01 1.28 0.33 16.16 −0.0619 −0.0125 <0.001 IntDiet Plat,Kat6a,Ank1,Ikbkb
OTU2243 Penicillium spathulatum Species 18 UNC29116030 9 41708067 41733945 0.025878 9.25 <0.01 12.97 0.54 29.59 −0.0099 −0.3142 0.0578 IntDiet Nearest gene AC154172.2,Gm35835, Gm48784, Gm35940
OTU2213 Penicillium spathulatum Species 18 UNC29082687 9.14 39047223 39715173 0.66795 9.38 <0.01 13.05 0.44 31.97 −0.0385 −0.3344 0.0514 IntDiet Nr3c1,Arhgap26
OTU298 Aspergillus nidulans Species 19 UNC30601828 8.87 60383903 61103683 0.71978 9.13 0.04 3.97 3.84 34.48 0.0137 0.1997 −0.2017 IntDiet Fam45a,Cacul1, Prlhr, Nanos1, Eif3a, Prdx3, Sfxn4, Grk5
OTU941 Aspergillus glabripes Species X UNC200105170 9.77 82219367 82464595 0.245228 10 0.04 3.97 0.01 86.09 −0.033 0.2072 −0.0592 IntDiet Gm24706

The table shows all mapped QTL derived from fungal DNA sequences across different models Add (host genetics-mycobiome interactions only), IntDiet (host genetics-diet interactions only), and IntSex (host genetics-sex interactions only) with taxonomical assignment of fungi from phylum to species level on chromosomal loci. Percentages of phenotypic variation for each QTL explained by sex, genetics, generation, diet, and cage are indicated as %h2 LOD, %h2 Sex, %h2 Generation (Gen), %h2 Diet, and % h2 Cage, respectively. Also, spearman’s correlation coefficients are displayed as ρ (Sex), ρ (Diet), and ρ (Gen).

The direction of the regression coefficient were obtained by converting categorical variable to quantitative variable.

Sex as males = 1 and females = 0; Diet as calorie-reduced = 0, control =1 and western = 2; Generation = 18, 19, and 20.