FIG 1.

GI TARGET program workflow: Genomic information is extracted from OncoPanels of patients with GI cancer and organized into a series of GI KBs to facilitate interpretation and review. A preliminary report is generated, which summarizes alterations of interest and current clinical trial options identified through MatchMiner. This information is reviewed in the context of relevant clinicopathologic information either through multidisciplinary molecular tumor board discussion or offline through molecular on-call. Consensus clinical recommendations and GI TARGET team discussion are summarized in the GI TARGET final report, which is e-mailed to the primary oncologist and uploaded to the EHR. AMP, amplification; CGS, clinical genomic scientist; Dx, diagnosis; EHR, electronic health record; GI AUTO, GI automated service; GI MO, GI medical oncologist; GI TARGET, Gastrointestinal Treatment Assistance Regarding Genomic Evaluation of Tumors; INDEL, insertion/deletion; KB, knowledgebase; MP, molecular pathologist; SNV, single nucleotide variant; SV, structural variant; Tx, treatment; VUS, variant of unknown significance.