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Generation of pathoblockers against PA by inhibition of quorum sensing via inverse agonists of the transcriptional regulator PqsR (MvfR). Multiple virulence mechanisms such as phenazine biosynthesis, AQ biosynthesis, antibiotic tolerance, iron uptake, T2SS, and T6SS as well as biofilm formation are under the control of PqsR.[ 13 , 14 ] The medicinal chemistry driven optimization strategy applied in this study is depicted in the inset in the top right corner.
