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X‐ray cocrystal structure of 24 in complex with PqsR. A) 3D rendering of the ligand–receptor complex. Protein surface and carbons are shown in cyan, carbons of compound 24 are shown in gray, nitrogen is blue, oxygen is red, fluorine is green, and chlorine is orange. Hydrogens left out for clarity. The inset shows a close‐up of the bi‐aryl ring system, highlighting the decreased angle of the indicated dihedral (white markings). B) 2D interaction scheme of compound 24.
