Figure 4.

The endogenous function of the circadian clock is not impaired in MitoPark mice. Representative double‐plotted actograms of rest/activity cycles from a A) control littermate and B) MitoPark mouse under LD and DD conditions. C) The phase angle of entrainment in LD was not affected in MitoPark mice (Control, n = 24 (12 males); MitoPark, n = 22 (10 males); t‐test, t ₄₄ = −0.141, p = 0.888). D) The endogenous free‐running period of rest/activity rhythm in DD was slightly increased in MitoPark mice (t‐test, t ₄₄ = −2.996, p = 0.004). E) The onset variability was not affected under DD in MitoPark mice (t‐test, t ₄₄ = 0.316, p = 0.754). F) The amplitude of rest/activity rhythms in DD was not affected in MitoPark mice (t‐test, t ₄₄ = 1.088, p = 0.282). G) The phase delay induced by 1 h light pulse at ZT14 was comparable between MitoPark and control littermates (t‐test, t ₄₄ = 0.612, p = 0.543). H,I) The circadian pattern of c‐fos expression in the suprachiasmatic nucleus, as revealed by immunohistochemistry, is not affected in MitoPark mice (n = 3–4 per time point, Two‐way ANOVA, F _1,7 = 0.37, p = 0.913). Scale bar in (H) = 250 µm. Data represent mean ± sem.