Table 2.

Sensitivity analysis of primary and secondary MR analyses.

Outcome	Number	R2	F	Heterogeneity test		MR-Egger pleiotropy test		MR-PRESSO global		MR-PRESSO
	of IVs							pleiotropy test		Distortion Test
				Q	p -value	Intercept	p -value	RSSobs	p -value	p -Value
Primary outcome	439	2.7527%	27.7101	598.4290	4.9487; e-07	−7.8420; e-05	0.0929	618.5921	< 5e-05	0.87425
Secondary outcome	462	2.8955%	29.3289	574.6058	2.3845; e-3	−5.7447; e-05	0.2339	577.3748	7e-04	NA