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. Author manuscript; available in PMC: 2023 Feb 15.
Published in final edited form as: Trends Mol Med. 2019 Oct 31;26(2):141–149. doi: 10.1016/j.molmed.2019.09.011

Figure 2. Factors sustaining high-level transcription of oncogenes.

Figure 2.

High-level transcription of oncogenes often is driven by enhancers and super-enhancers. This makes it strongly dependent on several conditions: (1) high levels of transcriptional co-activators (blue), (2) the 3D genome-mediated enhancer-promoter communications (gray), (3) the formation of phase-separated condensates (green), (4) chromatin-associated factors (chromatin remodelers, histone chaperones and histone-modifying enzymes; red), and (5) the loss of transcriptional repression (black). These dependencies make possible targeting oncogenes’ transcription with minimal effects on basal transcription.