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. 2023 Feb 14;14:835. doi: 10.1038/s41467-023-35797-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Sankey diagram depicting the association of samples classified into TF activity, proteome and phospho-proteome-based subtypes. b Sankey diagram depicting the association of samples classified into DGC proteomic cluster 2 and DGC TF subtypes. c Prognostic outcomes of GC patients in DGC proteomic subtype cluster 2. n (cluster 1) = 18 and n (cluster 2) = 10 biologically independent samples. The p-value is from Log-rank test. d TF activities comparison between two TF activity subtypes. e Prognostic outcomes of TFs with significantly differential activities in two TF activity subtypes. n = 28 biologically independent samples. The points and error bars show the median of hazard ratio (HR) and 95% confidence interval (CI). f Proteins expression of target genes of two TFs. g Pathways enriched in two subgroups of DGC proteomic subtype cluster 2. h Performance of the TF subtype predictor based on NFKB1 and SMARCC1. i The expression of NFKB1 and SMARCC1 in two subgroups. n (SMARCC1 subtype) = 28 and n (NFKB1 subtype) = 24 biologically independent samples. Boxplots show median (central line), upper and lower quartiles (box limits), min to max range. The p-value is calculated using two-sided student’s t-test. Source data are provided as a Source Data file.