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. 2022 Dec 21;10(5):2203742. doi: 10.1002/advs.202203742

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© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Administration process of in orthotopic glioma mice (A). Bioluminescence imaging of mice heads in different treatment groups (B). Enhanced effectiveness evaluation of ODP‐TH on the orthotopic glioma model. C) HE stained brain slices, glioma tissues were circled by dotted line(10×). D) Immunohistochemistry images of glioma tissues. (30×). E) Immunofluorescence images of glioma tissues stained with HIF‐1α antibody (red), Ki‐67 antibody (red), and MDR‐1 antibody (red) (20×). Mean ± SD, n = 3.