Table 3.

Effect of time passing on psychopathology.

	WAVE		Mean difference	Std. error	P-value	95% Confidence interval
Patient
PANSS	0	1	−3.406	0.885	< 0.001	−5.582	−1.230
	0	2	22.688	2.494	< 0.001	28.823	16.552
	1	2	−19.281	2.418	< 0.001	−25.229	13.334
YMRS	0	1	−2.667	2.682	NS	−10.756	5.422
	0	2	0.889	3.195	NS	−8.746	10.524
	1	2	3.556	4.46	NS	−9.895	17.006
BDI	0	1	−6.182	2.311	NS	−12.815	0.452
	0	2	−15.818	4.486	0.016	−28.693	−2.943
	1	2	−9.636	4.716	NS	−23.172	3.899
Relapse	0	1	−0.291	0.077	< 0.001	−0.48	−0.102
	0	2	−0.453	0.089	< 0.001	−0.67	−0.237
	1	2	−0.163	0.086	NS	−0.372	0.047
Rehospitalization	0	1	−0.023	0.033	NS	−0.104	0.057
	0	2	−0.058	0.042	NS	−0.16	0.044
	1	2	−0.035	0.042	NS	−0.137	0.068
Caregiver
GHQ	0	1	−3.279	0.568	< 0.001	−4.667	−1.892
	0	2	−22.326	3.348	< 0.001	−30.501	14.15
	1	2	19.047	3.287	< 0.001	−27.073	−11.02
FBIS	0	1	−2.535	0.25	< 0.001	−3.144	−1.925
	0	2	−31.767	3.214	< 0.001	−39.617	−23.918
	1	2	−29.233	3.181	< 0.001	−37.002	−21.463

PANSS, Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale; BECK, Beck Depression Inventory; GHQ, General Health Questionnaire; FBIS, Family Burden Interview Scale 1.