Fig. 1.

Kaplan-Meier curves of OXA killing of Schistosoma mansoni. A. OXA was tested in adult male worms at final concentrations of 143 μM, 71.5 μM, 35.75 μM, and 14.3 μM per well in vitro. Worms were challenged with OXA for 45 min. B. OXA was tested in adult male worms at final concentrations of 143 μM per well in vitro for 15, 30, or 45 min. After the indicated time, the well was washed with fresh medium three times to remove the drug. Survival was monitored in A. for 14 days and B. 14 days. All screens were performed in experimental and biological triplicate. Survival was plotted as a percentage over time using Prism/Curve Comparison/Long-rank (Mantel-cox) test. The p-value threshold for each OXA compared to DMSO was <0.001.