Fig. 5.

OXA Tissue Distribution in wild-type and P-gp knockout mice. OXA levels in bile and plasma were directly measured. Tissue levels in the liver, brain, and kidney were determined as the amount of drug per mg tissue and converted to μM by assigning a volume of 1 ml/g tissue. Samples were collected 4 h after a single oral dose of 100 mg/kg in C57Bl/6J (blue) and Mdr1KO (red) mice. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)