Table 1.
Human OXA Pharmacokinetic Parameters. Human parameters were from Table 2 and Fig. 1 in (Daneshmend and Homeida, 1987) and correspond to n = 9 patients and n = 5 healthy controls. Average values at individual time points were estimated from Fig. 1 and remodeled to calculate apparent oral clearance.
| T1/2 |
Cmax |
Tmax |
AUC(0-∞) |
Cl/F |
|
|---|---|---|---|---|---|
| (min) | (μM) | (min) | (μM*h) | (ml/min/kg) | |
| Patients | 151 ± 23 | 4.5 ± 0.9 | 103 ± 12 | 20.2 ± 4.9 | 62.0 |
| Normal subjects | 111 ± 14 | 7.1 ± 1.0 | 84 ± 25 | 24.9 ± 4.9 | 43.0 |
Values are presented as “mean ± SEM”.
Abbreviations: T1/2, elimination half-life; Cmax, maximum plasma concentration; Tmax, time to maximum plasma concentration; AUC(0-ꝏ), area under the curve from time 0 extrapolated to infinity, Cl/F apparent oral clearance.