Table 2.

Human OXA Hepatic Inlet Concentration. Average plasma concentrations from a human PK study of n = 9 patients and n = 5 healthy controls were from Fig. 1 in (Daneshmend and Homeida, 1987). Values were estimated and remodeled using two methods to determine the elimination and absorption rate constants. Only average plasma concentrations were reported so standard error was not calculated for human patients or controls.

	ke (1/min)		ka (1/min)		Inlet Concentration (μM)
	Residuals	WinNonlin®	Residuals	WinNonlin®	Residuals	WinNonlin®
Patients	0.003	0.004	0.027	0.022	94	78
Normal subjects	0.006	0.006	0.026	0.024	78	77

Values are presented as “mean”.

Abbreviations: k_e elimination rate constant; k_a absorption rate constant.