Table 4.
Mouse Hepatic Inlet Concentration. Mouse PK data was evaluated using WinNonlin® pharmacokinetic modeling software. Mouse PK parameters correspond to a 100 mg/kg oral gavage dose in n = 3 mice.
| ke (1/min) |
ka (1/min) |
Inlet Concentration (μM) |
||||
|---|---|---|---|---|---|---|
| Residuals | WinNonlin® | Residuals | WinNonlin® | Residuals | WinNonlin® | |
| OXA 100 mg/kg PO | 0.012 | 0.014 | 0.049 | 0.043 | 132 ± 11 | 118 ± 10 |
| 72229 100 mg/kg (Citr) PO | N.D. | 0.0042 | N.D. | 0.798 | N.D. | 51 ± 15 |
| 72229 100 mg/kg (Capt) PO | N.D. | 0.0039 | N.D. | 0.576 | N.D. | 219 ± 48 |
Values are presented as “mean” or “mean ± SEM”.
Abbreviations: ke elimination rate constant; ka absorption rate constant; N.D. not determined.
Citr, formulated in 100 mM citrate buffer, pH 3.5; Capt, formulated in 10% w:v Captisol.