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. 2023 Jan 4;42(4):e111549. doi: 10.15252/embj.2022111549

Figure EV5. HERC3 is positively correlated with poor prognosis in breast cancer.

Figure EV5

  1. HERC3 is highly expressed in breast cancer specimens. Representative images of IHC staining of HERC3 in breast tumor samples and adjacent normal tissues of tissue microarrays (Bioaitech). Scale bars, 50 μm.
  2. Graphical representation of scoring performed on IHC staining in Panel A. Data are represented as the mean ± SEM. n = 3 biological replicates. Statistical analysis was performed using two‐tailed Student's t‐test. ***P < 0.001.
  3. Expression level of HERC3 is positively correlated with those of YAP/TAZ target genes (e.g., CYR61, CCND1, CDH2, and PD‐L1) in breast cancer patients, as analyzed using TCGA database.
  4. YAP conserved signatures were enriched in breast cancer samples with high HERC3 levels. Transcriptome‐wide effects of HERC3 on YAP conserved signature genes in TCGA database were evaluated by GSEA analysis. Red, upregulated genes; blue, downregulated genes. NES = 1.36, P‐value < 0.05.