Figure 1.
Experimental design
The experimental cohort comprised 40 female Welsh ponies divided into four subgroups. The “HIGH-CTL” group corresponds to the high shedders and untreated ponies, whereas the “HIGH-TRT” group corresponds to the high shedders treated with pyrantel. The “LOW-CTL” group corresponds to the low shedders and untreated ponies, whereas the “LOW-TRT” group corresponds to the low shedders treated group. Sampling started on day 0 (before treatment with pyrantel) and ended on day 42 after treatment. The validation cohort included fecal microbiota profiles from four independently published studies. The four studies were Clark, Sallé, et al.,17 Peachey et al.,18 Kunz et al.,20 and Daniels et al.21