. 2023 Feb 14;329(6):472–481. doi: 10.1001/jama.2022.24162

Table 3. Secondary Outcomes of Changes in Spherical Equivalent and Axial Length Over 2 Years.

Follow-up	0.05% Atropine		0.01% Atropine		Placebo		P value
Follow-up	No. of patients	Mean (95% CI)^b	No. of patients	Mean (95% CI)^b	No. of patients	Mean (95% CI)^b	For trend^c	Overall^c	0.05% Atropine vs 0.01% atropine	0.05% Atropine vs placebo	0.01% Atropine vs placebo
Changes in spherical equivalent, D
2 wk	143	0.17 (0.13 to 0.21)	138	0.09 (0.05 to 0.12)	136	0.01 (−0.02 to 0.05)	<.001	<.001	.01	<.001	.007
4 mo	138	0.16 (0.11 to 0.21)	127	−0.01 (−0.06 to 0.04)	130	−0.15 (−0.21 to −0.10)	<.001	<.001	<.001	<.001	.002
8 mo	132	0.01 (−0.05 to 0.08)	131	−0.24 (−0.31 to −0.17)	120	−0.37 (−0.45 to −0.28)	<.001	<.001	<.001	<.001	.04
12 mo	136	−0.11 (−0.18 to −0.04)	139	−0.38 (−0.46 to −0.30)	128	−0.55 (−0.64 to −0.45)	<.001	<.001	<.001	<.001	.03
16 mo	124	−0.25 (−0.35 to −0.15)	132	−0.56 (−0.66 to −0.46)	124	−0.69 (−0.80 to −0.59)	<.001	<.001	<.001	<.001	.11
20 mo^a	95	−0.38 (−0.51 to −0.24)	92	−0.71 (−0.85 to −0.56)	88	−0.83 (−0.98 to −0.69)	<.001	<.001	.003	<.001	.39
24 mo	116	−0.46 (−0.58 to −0.33)	122	−0.84 (−0.98 to −0.70)	115	−1.01 (−1.15 to −0.87)	<.001	<.001	<.001	<.001	.19
Changes in axial length, mm
2 wk	140	0.01 (0.00 to 0.02)	136	0.02 (0.01 to 0.02)	135	0.04 (0.03 to 0.05)	.001	.003	.35	.001	.005
4 mo	137	0.08 (0.06 to 0.10)	125	0.11 (0.10 to 0.13)	129	0.16 (0.13 to 0.18)	<.001	<.001	.06	<.001	.01
8 mo	131	0.16 (0.14 to 0.19)	129	0.24 (0.21 to 0.27)	120	0.30 (0.27 to 0.34)	<.001	<.001	<.001	<.001	.04
12 mo	135	0.25 (0.22 to 0.28)	137	0.34 (0.31 to 0.37)	127	0.40 (0.36 to 0.45)	<.001	<.001	<.001	<.001	.09
16 mo	123	0.33 (0.29 to 0.38)	130	0.46 (0.41 to 0.51)	123	0.51 (0.46 to 0.56)	<.001	<.001	<.001	<.001	.18
20 mo^a	94	0.42 (0.36 to 0.48)	92	0.56 (0.50 to 0.63)	87	0.60 (0.54 to 0.66)	<.001	<.001	.001	<.001	.74
24 mo	114	0.48 (0.42 to 0.53)	120	0.63 (0.57 to 0.70)	115	0.70 (0.64 to 0.76)	<.001	<.001	<.001	<.001	.30

^{^a}

A proportion of participants did not attend the 20-month visit because of the infection control restriction during the COVID-19 pandemic.

^{^b}

Mean and 95% CI values were calculated with data from both eyes.

^{^c}

P values were generated by the generalized estimating equation model with the adjustment of baseline age, sex, baseline spherical equivalent/axial length, outdoor time, near work time, and parental myopia.