Table 1.
General description of the eight MPNST cell lines analyzed
| S462 | ST88-14 | NF90-8 | sNF96.2 | NMS-2 | STS-26T | HS-Sch-2 | HS-PSS | |
|---|---|---|---|---|---|---|---|---|
| Type of human MPNST | primary, grade IV | primary | primary, from PNF | primary | primary | metastasis, grade III/III | primary, low grade | UNK |
| MPNST localization | thigh | retroperitoneum | left forearm | leg | right thigh | left scapula | left thigh | prostate |
| NF1/Sp | NF1 | NF1 | NF1 | NF1 | NF1 | Sp | Sp | Sp |
| Age of patient | 19 | 24 | 17 | 27 | 30 | 51 | 54 | UNK |
| Sex of patient | F | M | F | M | M | F | F | M |
| Original Reference | Frahm-2004 | Fletcher-1991 | Legius-1994 | Perrin-2007 | Imaizumi-1998 | Dahlberg-1993 | Sonobe-2000 | n/a |
| NF1 constitutional pathogenic variant | c.6855C>A p.Y2264X Frahm-2004 | c.1649dupT p.V551Gfs∗7 Varin-2016 | c.3904_3910del p.D1302Yfs∗5 Wu-1999 | c.3683delC p.N1229Mfs∗11 Perrin-2007 | c.6999+1G>T (splice donor) | |||
| NF1 somatic pathogenic variant | LOH | LOH | LOH | LOH | LOH | LOH |
c.270_288del p.E91Nfs∗6; c.3113+1G>A (splice donor) |
MPNST: Malignant peripheral nerve sheath tumor; NF1/Sp: NF1-related/Sporadic MPNST; F:Female; M: Male; Bold annotations: mutations described in this article; LOH: Loss of Heterozygosity; UNK: Unknown.