Table 3.

Whole-brain and region of interest (ROI) effects of diagnosis on brain activation during reward anticipation and delivery^a

	Effect of diagnosis	Direction	k	x	y	z	F	P(FWE-corr)
Anticipation
Whole brain	Right caudate	Typically developing > ASD	8	12	17	−4	22.844	0.0169
ROI	Left ventral striatum: F(1,384) = 14.163, P < 0.001, partial η2 = 0.036 Right ventral striatum: F(1,384) = 18.693, P < 0.001 partial η2 = 0.046
Delivery
Whole brain	all F < 20.88, PFWE > 0.05
ROI	Left ventral striatum: F(1,370) = 4.829, P = 0.029, partial η2 = 0.013 Right ventral striatum: F(1,370) = 4.719, P = 0.030, partial η2 = 0.013

ASD, autism spectrum disorder.

^a.Table provides test statistic for whole brain and ROI analysis for diagnosis. Voxel-level statistics were family-wise error (FWE) corrected for the number of voxels across the whole brain for each test. Significance was defined as P_FWE < 0.05 with a cluster threshold of k ≥ 5. For ROI analysis in the left and right ventral striatum, the critical alpha level was adjusted to P < 0.025 to control for multiple comparisons. Small effect sizes correspond to partial η² > 0.00995, medium effect sizes correspond to partial η² > 0.0588 and large effect sizes correspond to partial η² > 0.1379.