表 3. Global research hotspots on oncology: nervous system and head/face tumor.

肿瘤领域全球研究热点——神经系统与头面部肿瘤

研究主题	相关研究	被引次数 查询时间 2020.09.23	期刊来源
神经系统肿瘤
临床试验	Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease（NCCTG N107C/CEC·3）：a multicentre，randomised，controlled，phase 3 trial[17]	260	Lancet Oncol
	Rindopepimut with temozolomide for patients with newly diagnosed，EGFRvIII-expressing glioblastoma（ACT IV）：a randomised，double-blind，international phase 3 trial[18]	231	Lancet Oncol
	Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma：a randomized clinical trial[19]	325	JAMA
长链非编码 RNA	Long noncoding RNA NEAT1，regulated by the EGFR pathway，contributes to glioblastoma progression through the WNT/β-catenin pathway by scaffolding EZH2[20]	105	Clin Cancer Res
头面部肿瘤
临床试验	Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer：results from a single-arm，phase II study[21]	222	J Clin Oncol
	Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer（De-ESCALaTE HPV）：an open-label randomised controlled phase 3 trial[22]	162	Lancet
	Pembrolizumab versus methotrexate，docetaxel，or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma（KEYNOTE-040）：a randomised，open-label，phase 3 study[23]	221	Lancet
	Nivolumab for recurrent squamous-cell carcinoma of the head and neck[24]	1 505	N Engl J Med
	Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases：a multicentre randomised phase 2 study[25]	239	Lancet
单细胞转录组分析	Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer[26]	317	Cell