. Author manuscript; available in PMC: 2023 Nov 16.

Published in final edited form as: Nature. 2022 Nov 16;611(7937):818–826. doi: 10.1038/s41586-022-05432-3

Table 1.

Summary of TCR CDR3, V and J genes for TCRs used in antigen discovery experiments.

TCR ID	TCR Source	β CDR3	TRBV	TRBJ	α CDR3	TRAV	TRAJ	Antigen
A	Murine single cell sequencing	CSAAWGGSAETLYF	TRBV1	TRBJ2-3	CAVSDRGSALGRLHF	TRAV7-3*04	TRAJ18	MYH6_191-198 (VIQYFASI)
1	Murine single cell sequencing	CASSPGQGAYAEQFF	TRBV12-2	TRBJ2-1	CAVSSGYGSSGNKLIF	TRAV7-5	TRAJ32	Unknown (Not in α-myosin, SBK2, ANP, BNP)
2	Murine single cell sequencing	CASKTGYNYAEQFF	TRBV19	TRBJ2-1	CALNTGYQNFYF	TRAV4-4-DV10	TRAJ49	Unknown (Not in α-myosin, SBK2, ANP, BNP)
3	Murine single cell sequencing	CASGGLGGPSQNTLYF	TRBV12-2	TRBJ2-4	CALERSTGNYKYVF	TRAV13-1	TRAJ40	Unknown (Not in α-myosin, SBK2, ANP, BNP)
4	Murine single cell sequencing	CASSDAGYAEQFF	TRBV13-3	TRBJ2-1	CALGDSNYQLIW	TRAV6-6	TRAJ33	Unknown (Not in α-myosin, SBK2, ANP, BNP)
B	Adoptive transfer (Donor, Rec1,3,4)	CASSLRRGEQYF	TRBV15	TRBJ2-7	CALERASGSWQLIF	TRAV13-1	TRAJ22	MYH6_191-198 (VIQYFASI)
C	Adoptive Transfer (Rec2)	CASSLGGTVQDTQYF	TRBV12-2	TRBJ2-5	CALGDRNNAGAKLTF	TRAV6D-6	TRAJ39	MYH6_418-425 (VQQVYYSI)
TCR_pt1	Pt 1 exPBMC (single cell sequencing)	CASSPYQSSGANVLTF	TRBV9	TRBJ2-6	CALSDRYGGATNKLIF	TRAV19	TRAJ32	MYH6_443-451 (RINATLETK)