Recommendation	Class	Level	Reference
As reduced dosing frequency is associated with better adherence, antihypertensive drugs are recommended to be administered once a day unless there are special situations such as resistant hypertension, morning hypertension, medication adjustment.	I	A	[108, 109]
In stable patients with the same drug and dosage during a long period of time, it is reasonable to use fixed-dose combination drugs because their drug adherence is better than that of free combination drugs.	IIa	B	[110, 111]
The use of the fixed-dose combination of antihypertensive drugs and statins to increase adherence to drug therapy may be considered.	IIb	B	[112]