TABLE 2.
Correlations between overall survival and mRNA expression of VEGFA analysed by univariate and multivariate Cox regression
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | ||
| Age | 373 | ||||
| <=60 | 177 | Reference | 0.295 | ||
| >60 | 196 | 1.205 (0.850–1.708) | |||
| T stage | 370 | ||||
| T1&T2 | 277 | Reference | ＜0.001 | 0.645 | |
| T3&T4 | 93 | 2.598 (1.826–3.697) | 1.603 (0.215–11.974) | ||
| N stage | 258 | ||||
| N0 | 254 | Reference | 0.324 | ||
| N1 | 4 | 2.029 (0.497–8.281) | |||
| M stage | 272 | ||||
| M0 | 268 | Reference | 0.017 | 0.226 | |
| M1 | 4 | 4.077 (1.281–12.973) | 2.089 (0.634–6.889) | ||
| Pathologic stage | 349 | ||||
| Stage I & Stage II | 259 | Reference | <0.001 | 0.592 | |
| Stage III & Stage IV | 90 | 2.504 (1.727–3.631) | 1.736 (0.230–13.082) | ||
| Histologic grade | 368 | ||||
| G1&G2 | 233 | Reference | 0.636 | ||
| G3&G4 | 135 | 1.091 (0.761–1.564) | |||
| Adjacent hepatic tissue inflammation | 236 | ||||
| None | 118 | Reference | 0.475 | ||
| Mild&Severe | 118 | 1.194 (0.734–1.942) | |||
| Vascular invasion | 317 | ||||
| No | 208 | Reference | 0.163 | ||
| Yes | 109 | 1.344 (0.887–2.035) | |||
| Gender | 373 | ||||
| Female | 121 | Reference | 0.200 | ||
| Male | 252 | 0.793 (0.557–1.130) | |||
| VEGFA | 373 | 1.331 (1.071–1.655) | 0.010 | 1.028 (0.780–1.354) | 0.845 |