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. 2023 Jan 13;34(2):ar9. doi: 10.1091/mbc.E22-06-0236

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FIGURE 2: — Ras promotes the migration of MCF10A and breast cancer cells. Wound closure cell migration assays were performed in the presence of prenyltransferase inhibitors (PTIs), or 0.1% DMSO control; and with cells previously treated with siRNAs to silence H-, N-, and K-Ras (Pan-Ras), or nontargeting (NT) siRNAs as control, as described in the Materials and Methods section. (A) MCF10A cell migration. (B) HER2/MCF10A cell migration. (C) MCF7, MDAMB231, and MDAMB453 cell migration. Graphs show the measured migration distances ±SD of at least six wounds from at least three independent experiments. *, p < 0.05; **, p < 0.01.