FIGURE 9:

Model for SPOC slippage. Spindle misorientation activates the SPOC kinase Kin4, which in turn keep the GAP complex Bfa1-Bub2 active. As a consequence, MEN is inhibited, and cells arrest in late anaphase until spindle misorientation is corrected. A robust late anaphase arrest requires the presence of SWR1-C to prevent mitotic slippage in SPOC-arrested cells most likely via transcriptional regulation. Mitotic slippage in the absence of SWR1-C requires Sir2, FEAR proteins Slk19 and Spo12, CWI pathway kinase Slt2, CKI Sic1, SAGA component Sgf73, and the proteosome component Pre9 as depicted. See text for details.