Table 4.

LMR Ratio in Various Studies.^63–98

Authors	Study Group	Control Group	LMR values		P value	Cut Off	AUC	Specificity (%)	Sensitivity (%)	Observations
	N	N	Study	Control
Bilge et al 202166	Cancers n=75	No cancers n=111	0.16	0.14	NS	-	-	-	-	There is no significant differences in LMR between the two groups compared in this study.
Waris et al 202190	Mild n=52 Moderate n=24 Severe n=9 Critical n=16		Mild= 8.32 Moderate=5.74 Severe=5.54 Critical=4.37		0.011	-	-	-	-	LMR can be useful for clinicians to identify potentially severe cases at early stages, initiate effective management in time, and conduct early triage which may reduce the overall mortality of COVID-19 patients.
Zhao et al 202063	Severe n=74	Mild n=211	1.88	3.13	<0.001	3.13	0.73	81%	58%	LMR reflects the intensity of inflammation and is associated with severity of patients with COVID-19.
Ramos-Peñafiel et al 202067	Death n=54	Alive n=71	0.53	0.37	0.004	-	-	-	-	MLR can predict SARS-CoV-2 infection-associated mortality.
Citu et al 202281	Deaths n=17	Survivors n=91	0.83	0.53	0.01	0.69	0.661	74%	58%	MLR determined at hospital admission have a high value in predicting death among patients with COVID-19.
Moisa et al 202182	Non-survivors n=142	Survivors n=130	0.69 ± 0.4	0.61 ± 0.44	0.017	-	-	-	-	MLR shows a little effectiveness in assessing the risk of death.
Fois et al 202086	Non-survivors n=29	Survivors n=90	0.429	0.333	0.058	-	-	-	-	Changes in the MLR value between the control group and the study group are not sufficient to demonstrate statistical significance.
Çalışkan et al 202295	Severe (n = 113)	Non-severe (n = 435)	0.36	0.5	0.001	≤0.49	0.605	50.89	73.15	MLR is higher in the severe group compared to non-severe group of patients with COVID-19.
Noor et al 202096	Severe n=370	Non-severe n=365	6.635	10.548	<0.001	-	0.262	-	-	LMR could not be a diagnostic factor for severity of disease because the AUC was less than 0.50.
Lissoni et al 202097	n=17	n=100	2.7	5.8	<0.001	-	-	-	-	LMR values are abnormally low and LMR mean values observed in COVID-19 patients were significantly lower than in the control group.
Eissa et al 202198	n=88	n=41	3.94	5	<0.001	6	0.738	65.9	71	LMR have a high sensitivity (71%, cutoff <6).
Anurag et al 202044	Mild=116 Moderate=12 Severe=20		Mild=5.16 Moderate= 3.16 Severe = 5.14		0.565	-	-	-	-	There are no statistically significant differences in the LMR values in patients with different clinical conditions in COVID-19.

Abbreviations: ICU, intensive care unit patients; non-ICU, non-intensive care unit patients; IMV, invasive mechanical ventilation; ICU-LOS, ICU length of stay; MLR, monocytes to lymphocytes ratio.