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. 2023 Feb 14;11(2):e005126. doi: 10.1136/jitc-2022-005126

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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GLIS1 was upregulated in exhausted CD8⁺ T cells based on GEO database. (A) We cross-analyzed the differential genes at day 8 and day 30 of acute and chronic viral infection from GSE84820 data to find shared common genes. (B) Heatmap concretely showing shared common genes including GLIS1. (C, D) GLIS1 expression at day 8 and day 30 of acute and chronic viral infection respectively based on GSE84820 data.(E) KEGG pathway enrichment results based on GSE84820 data analysis. (F) GO analysis of GSE84820. (G, H) GSEA pathway enrichment results based on GSE155192 data analysis. (I, J) GSEA pathway enrichment results based on GSE84820 data analysis. (K) The relationship between GLIS1 and CD8 T cell exhausted markers expression based on based on GSE155192 and GSE 84820 data.