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. 2023 Feb 15;2023(2):CD011507. doi: 10.1002/14651858.CD011507.pub3

Comparison 1. Myo‐inositol versus control.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Gestational diabetes mellitus 6 1140 Risk Ratio (M‐H, Random, 95% CI) 0.53 [0.31, 0.90]
1.2 Fasting OGTT 5 1071 Mean Difference (IV, Fixed, 95% CI) ‐0.14 [‐0.21, ‐0.07]
1.3 One hour OGTT 5 1071 Mean Difference (IV, Fixed, 95% CI) ‐0.34 [‐0.55, ‐0.14]
1.4 Two hour OGTT 5 1071 Mean Difference (IV, Random, 95% CI) ‐0.38 [‐0.77, 0.01]
1.5 Hypertensive disorders of pregnancy 5 1052 Risk Ratio (M‐H, Random, 95% CI) 0.34 [0.19, 0.61]
1.6 Large‐for‐gestational‐age 1 234 Risk Ratio (M‐H, Fixed, 95% CI) 1.40 [0.65, 3.02]
1.7 Caesarean section 4 829 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.77, 1.07]
1.8 Weight gain during pregnancy 4 831 Mean Difference (IV, Random, 95% CI) ‐0.25 [‐1.26, 0.76]
1.9 Relevant biomarker changes associated with the intervention 3   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.9.1 Total cholesterol 3 340 Mean Difference (IV, Fixed, 95% CI) ‐29.57 [‐32.80, ‐26.33]
1.9.2 Low density lipoprotein 3 340 Mean Difference (IV, Fixed, 95% CI) ‐22.43 [‐25.86, ‐19.00]
1.9.3 High density lipoprotein 3 340 Mean Difference (IV, Fixed, 95% CI) ‐1.46 [‐2.72, ‐0.20]
1.9.4 Triglycerides 3 340 Mean Difference (IV, Fixed, 95% CI) ‐24.92 [‐27.82, ‐22.02]
1.10 Perineal trauma 1 234 Risk Ratio (M‐H, Fixed, 95% CI) 4.00 [0.45, 35.25]
1.11 Postpartum haemorrhage  1 234 Risk Ratio (M‐H, Fixed, 95% CI) 0.67 [0.31, 1.42]
1.12 Adherence to intervention 1 240 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.84, 1.16]
1.13 Supplementary insulin 3 595 Risk Ratio (M‐H, Fixed, 95% CI) 0.50 [0.17, 1.52]
1.14 Gestational age at birth 4 829 Mean Difference (IV, Random, 95% CI) 3.69 [‐1.48, 8.86]
1.15 Preterm birth (less than 37 weeks' gestation) 4 829 Risk Ratio (M‐H, Fixed, 95% CI) 0.35 [0.17, 0.70]
1.16 Macrosomia 4 829 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.16, 1.96]
1.17 Birthweight 4 829 Mean Difference (IV, Random, 95% CI) ‐8.65 [‐140.36, 123.07]
1.18 Shoulder dystocia 4 829 Risk Ratio (M‐H, Random, 95% CI) 1.43 [0.15, 13.54]
1.19 Respiratory distress syndrome 2 431 Risk Ratio (M‐H, Fixed, 95% CI) 1.49 [0.25, 8.85]
1.20 Neonatal hypoglycaemia 4 671 Risk Ratio (M‐H, Fixed, 95% CI) 3.07 [0.90, 10.52]
1.21 Small‐for‐gestational‐age 1 234 Risk Ratio (M‐H, Fixed, 95% CI) 2.33 [0.62, 8.80]
1.22 Neonatal hyperbilirubinaemia 1 234 Risk Ratio (M‐H, Fixed, 95% CI) 0.25 [0.05, 1.15]
1.23 Admission to neonatal intensive care unit or special care baby unit 2 435 Risk Ratio (M‐H, Fixed, 95% CI) 0.40 [0.14, 1.18]