Esmaeilzadeh 2021.

Methods	Study type: double‐blind randomised controlled trial
Participants	Inclusion criteria: 76 singleton, overweight, pregnant women (pre‐pregnancy body mass index ≥ 25 and < 30 kg/m2), aged 18 to 40, were enrolled at their first visit.
Interventions	Intervention: daily intake of 2000 mg myo‐inositol plus 200 micrograms folic acid from 14 to 24 gestational weeks Control: daily intake of 400 µg of folic acid from 14 to 24 gestational weeks
Outcomes	Primary outcome: gestational diabetes at 24 to 28 gestational weeks Secondary outcomes: evaluation of insulin resistance and lipid profile, insulin therapy, inappropriate gestational weight gain, caesarean section, pregnancy‐induced hypertension, pre‐eclampsia, preterm delivery, fetal macrosomia, shoulder dystocia, neonatal respiratory distress syndrome, and neonatal intensive care unit (NICU) admissions. The occurrence of adverse drug effects caused by intervention such as the presence of uterine contractions, headache, nausea, vomiting, diarrhoea, tiredness, and atulence were all assessed during follow‐up visits.
Notes