Table 1.
Main demographic and clinical characteristics of the participants.
| Characteristic | CN | aMCI_C | aMCI_S | Statistics | P values | CN vs. aMCI_C P values | aMCI_C vs. aMCI_S P values | Validation (CN to AD) |
|---|---|---|---|---|---|---|---|---|
| Number of subjects | 232 | 276 | 279 | – | – | – | – | 24 |
| Total no. of sMRI scans | 1265 | 1709 | 1669 | – | – | – | – | 189 |
| Age at first sMRI scan (years) | 73.87 ± 6.12 | 74.12 ± 6.80 | 73.99 ± 7.56 | F = 0.086 | 0.918 | – | – | 75.68 ± 4.39 |
| Gender (males/females) | 114/118 | 162/114 | 164/115 | χ 2 = 6.118 | 0.047 | 0.031 | 0.984 | 8/16 |
| Education (years) | 16.66 ± 2.52 | 16.04 ± 2.73 | 15.79 ± 2.92 | F = 6.584 | 0.001 | 0.009 | 0.303 | 15.71 ± 2.68 |
| APOE ε4 (carriers/noncarriers)a | 67/165 | 183/93 | 120/159 | χ 2 = 73.652 | <0.001 | <0.001 | <0.001 | 10/14 |
| No. sMRI scans per subject | 5.45 ± 2.43 | 6.19 ± 2.25 | 5.98 ± 1.74 | F = 7.844 | <0.001 | <0.001 | 0.219 | 7.88 ± 2.67 |
| Follow-up duration (years) | 4.20 ± 2.98 | 3.86 ± 2.32 | 3.72 ± 2.24 | F = 2.388 | 0.093 | – | – | 7.08 ± 3.25 |
| First sMRI scan | ||||||||
| ADAS13 | 9.32 ± 4.55 | 20.91 ± 6.74 | 15.09 ± 5.25 | F = 260.22 | <0.001 | <0.001 | <0.001 | 9.74 ± 3.98 |
| CDRSB | 0.00 ± 0.00 | 1.97 ± 0.94 | 1.26 ± 0.63 | F = 548.72 | <0.001 | <0.001 | <0.001 | 0.00 ± 0.00 |
| MMSE | 29.06 ± 1.17 | 26.91 ± 1.87 | 27.81 ± 1.79 | F = 103.31 | <0.001 | <0.001 | <0.001 | 29.42 ± 0.95 |
| RAVLT immediate | 45.01 ± 10.10 | 29.28 ± 8.71 | 35.07 ± 9.88 | F = 168.89 | <0.001 | <0.001 | <0.001 | 43.00 ± 9.43 |
a APOE ε4 carriers indicate subjects having one or two copies of ε4 alleles. Continuous variables are shown as “mean ± standard deviation.” P values in bold indicate significant differences between groups.