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. Author manuscript; available in PMC: 2023 Jul 4.
Published in final edited form as: Nature. 2023 Jan 4;613(7943):383–390. doi: 10.1038/s41586-022-05565-5

Fig. 2: Architecture of the METTL1-WDR4-tRNA complex in three states.

Fig. 2:

a-c, Models of the cryo-EM structures in the indicated cofactor binding states, in cartoon representation. METTL1, WDR4, tRNA and SAM/SAH are colored blue, green, gold, and magenta, respectively. d, Superimposition of the apo and SAH-bound cryo-EM structures of METTL1-WDR4-tRNA, aligning by WDR4. METTL1 moves closer to tRNA in the presence of SAH (black dashed arrow). e, Zoomed-in view of (d) showing the tRNA and the catalytic loop protruding toward the tRNA (black dashed arrow).