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. Author manuscript; available in PMC: 2023 Nov 16.
Published in final edited form as: J Am Chem Soc. 2022 Nov 2;144(45):20815–20824. doi: 10.1021/jacs.2c08770

Figure 6.

Figure 6.

Fragment 3 reduces cell proliferation via the miR-372–LATS2 circuit. (A) siRNA knockdown of LATS2 in the presence and absence of 3, as measured by RT-qPCR. (B) Effect of 3 on cell proliferation of AGS cells upon siRNA knockdown of LATS2, as determined by MTS assay. (C) Effect of fragment 3 on the proliferation of AGS cells forced to overexpress pre-miR-372 (n = 6). Overexpression of the target leads to ablation of the compound’s effect. (D) Effect of 3 on proliferation of NCI-N87 cells forced to express pre-miR-372 (n = 6). *P < 0.05, ***P < 0.001, and ****P < 0.0001 as determined by one-way ANOVA compared to untreated samples. Data are reported as the mean ± SEM for all panels.