Table 1.

JAK proteins and their cytokines

JAK protein	Cytokines
JAK1	IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-11, IL-15, IL-19, IL-20, IL-21, IL-22, IL-27, LIF, OSM, IFN-alpha, IFN-beta, IFN-gamma
JAK2	IL-3, IL-5, IL-6, IL-11, IL-12, IL-23, IL-27, GM-CSF, LIF, OSM, erythropoietin, thrombopoietin, leptin, growth hormone
JAK3	IL-2, IL-4, IL-7, IL-9, IL-15, IL-21
Tyk2	IL-6, IL-10, IL-11, IL-12, IL-19, IL-20, IL-21, IL-22, IL-23, IL-27, LIF, OSM, IFN-alpha, IFN-beta,

JAK Janus kinase, IL interleukin, LIF leukemia inhibitory factor, OSM oncostatin M IFN interferon, EPO erythropoietin, G-CSF granulocyte colony-stimulating factor, GH growth hormone, GM-CSF granulocyte–macrophage colony-stimulating factor, TPO thrombopoietin, Tyk2 tyrosine kinase 2