Table 3.

Conditions where JAK inhibitor use is not appropriate

JAK inhibitor use has higher risks in the following conditions:

Active cancer (or history of several cancers)

Active or recurrent shingles despite vaccination

Severe recurrent infections and/or frequent hospitalizations for serious infections

Previous DVT and/or high risk for DVT without receiving anticoagulation

Pregnancy, breast-feeding, and/or patients considering pregnancy

Patients receiving other immunosuppressive therapies, such as transplant patients

Severe organ failure such as decompensated cirrhosis and end-stage renal disease requiring dialysis due to limited data in these populations