Oral Janus kinase (JAK) inhibitors had low rates of venous thromboembolism, major adverse cardiovascular events, and malignancy compared with similarly low rates in the placebo in their use in clinical trials in dermatology.

Most patients who developed serious adverse events had risk factors specific to the event.

The most common treatment emergent adverse events observed in ≥ 5% of patients on oral JAK inhibitors included upper respiratory tract infection, nasopharyngitis, nausea, headache, and acne.

A comprehensive evaluation of a patient’s baseline risk factors for complications and comorbid diseases is critical in assessing the net benefit of JAK inhibitors on a case-by-case basis.