Table 3.

Results of the meta-analysis of severe exacerbation rates.

Study	Sample size	Proportion (%)	95% CI	Weight (%)
				Fixed	Random
Backer 2018	2539	9.8	8.6–10.9	52.8	21.4
Park 2019	85	15.3	8.4–24.7	1.8	17.5
Schmidt 2017	1410	5.9	4.7–7.3	29.4	21.2
Wan 2017	618	25.9	22.5–29.5	12.9	20.9
Usmani 2017	151	4.6	1.9–9.3	3.2	19.0
Total (fixed effects)	4803	10.1	9.3–10.9	100.0	100.0
Total (random effects)	4803	11.5	5.8–18.7	100.0	100.0