Table 3.

Characterizations of the optimum formulae of the studied nanosystems.

Route	Topical		Ocular			Vaginal
Nanosystem	T-T-NV	T-CE	O-NV	O-OLN	O-TP	V-TP
EE %	100.00 ± 1.10	83.00 ± 1.63	94.31 ± 2.75	84.24 ± 1.28	79.02 ± 2.35%	62.18 ± 1.39%
PS (nm)	358.60 ± 10.76	551.60 ± 23.84	197.05 ± 9.97	117.55 ± 5.44	287.25 ± 9.55	310.00 ± 8.16
ZP (absolute -mV)	30.00 ± 0.80	20.90 ± 0.55	66.95 ± 0.92	74.85 ± 1.91	36.15 ± 1.06	10.19 ± 0.2
Release (8h)	< 40 %	not studied	85.33 ± 1.35	77.95 ± 1.22	>80%	not studied

Abbreviations: EE %, percent entrapment efficiency; PS, particle size; ZP, zeta potential.

Nanosystems: O-NV, Ocular Novasomes; O-OLN, Ocular Olaminosomes; O-TP, Ocular Terpesomes; T-CE, Topical cerosomes; T-T-NV, Topical Trans-Novasomes; V-TP, Vaginal Terpesomes.