Table 1.

Target population*† .

	Year 1	Year 2	Year 3	Reference
Italian population
General population	58,928,122			[28]
Prevalent FMF PTS
Prevalence of FMF	1/60,000			[6]
FMF Prevalent PTS (n)	982
FMF PTS intolerant to colchicine	3.5%			[12–16]
FMF PTS resistant/non-responder to colchicine	7.5%			[12–16]
FMF prevalent PTS intolerant OR resistant/non-responder to colchicine (n)	105
Incident FMF PTS
Incident FMF PTS (n)	40	40	40	[29]
FMF Pts intolerant to the colchicine	3.5%	3.5%	3.5%	[12–16]
FMF PTS resistant/non-responder to colchicine	7.5%	7.5%	7.5%	[12–16]
FMF prevalent PTS intolerant OR resistant/non-responder to colchicine (n)	4	4	4
Target population
Total FMF PTS treated with biologics (n)	109	113	117
Percent of PTS treated with anakinra and canakinumab (on-label biologicals)	70%	70%	70%	[30]
Of whom PTS treated with anakinra and canakinumab (on-label biologicals) (n)	76	79	82

Legend: FMF: Familial Mediterranean Fever; PTS: Patients; n: number.

*Number of patients rounded at the first integer. †Percentages rounded to the first decimal number.