Table S2.

Number of events, incident rates, and hazard ratios (HRs) of health outcomes.

	NF/FL alone			NF/FL + SMS co-treatment			HR (95% CI)	P value
	No. of event	Follow-up duration (person-year)	Incident Rate (per 1,000 person-year)	No. of event	Follow-up duration (person-year)	Incident Rate (per 1,000 person-year)
Headache	638	11,173.72	57.10	205	2,211.36	92.70	1.68 (1.44–1.97)	< 0.0001
LBP	56	12,234.00	4.58	14	2,537.76	5.52	1.24 (0.69–2.23)	0.4678
AMI	75	12,234.00	6.13	20	2,537.76	7.88	1.33 (0.81–2.18)	0.2533
HHF	292	11,907.76	24.52	58	2,472.48	23.46	0.99 (0.75–1.31)	0.9446
All cause death	486	12,315.56	39.46	61	2,570.40	23.73	0.60 (0.46–0.78)	0.0002
Bone fracture	39	12,274.78	3.18	3	2,562.24	1.17	0.38 (0.12–1.24)	0.1096

Abbreviations: LBP, low blood pressure; AMI, acute myocardial infraction; HHF: hospitalization due to heart failure. There were 4,078 and 816 patients included in the data analyses of groups taking nifedipine/felodipine without (NF/FL alone) and with the co-treatment with Shengmai-San (NF/FL + SMS co-treatment), respectively. Low blood pressure: systolic blood pressure < 90 mm-Hg or diastolic blood pressure <60 mm-Hg.