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. 2023 Feb 1;12:985827. doi: 10.3389/fonc.2022.985827

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Copyright © 2023 Xu, Wang, Mo, Xie, Hu, Jiang, Hu, Ding and Xiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NLE1 depletion inhibits xenograft tumors in non−small−cell lung cancer. (A) A nude mice model was constructed through subcutaneously injecting NLE1-deficient A549 cells. (B, C) Following cell implantation, the fluorescence intensity (B) and tumor volume (C) were evaluated at indicated time. (D) The photos of tumors removed from mice models were collected. (E) The weight of xenografted tumors was measured. (F) The pattern of Ki-67 was detected via IHC staining in tumor sections from the mice models. (G) A diagram depicting the mechanism by which NLE1 regulates the development of non−small−cell lung cancer. The data were expressed as mean ± SD (n ≥ 3). ** P < 0.01.