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. 2023 Feb 15;9(7):eadd2911. doi: 10.1126/sciadv.add2911

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Fig. 2. — (A) The expression level of genes near the de novo gained enhancers is increased. (B) Gained enhancers are enriched near the genes that are mostly highly expressed in humans as compared to rhesus macaque. (C) Average number of eQTLs per enhancer. (D) Biological processes that are associated with gained enhancers based on whole-genome region enrichment analysis performed using the GREAT tool (57). (E) Biological processes that are associated with lost enhancers based on GREAT whole-genome region enrichment. (F) The CNS-related GWAS traits are enriched in the gained enhancers compared to both lost and conserved enhancers.