Fig. 3. The de novo gained enhancers are enriched in the progenitor cells and interneurons.
(A) The de novo gained enhancers are significantly enriched in the most highly expressed genes of embryonic human neocortex but no other adult brain regions. **P < 1 × 10−3, Fisher’s exact test. (B) Scatterplot visualization of cells after principal components analysis and t-distributed stochastic neighbor embedding (tSNE), colored by Seurat clustering and annotated by major cell types. (C) Fraction of enhancers near genes that are most highly expressed in all the cell clusters.