. 2023 Feb 15;9(7):eabq1141. doi: 10.1126/sciadv.abq1141

Table 1. Different inflammatory biomarkers for distinguishing synucleinopathy disorders.

↑, increased expression; ↓, decreased expression; −, not significant; /, not measured.

Methods	Samples	Markers	PD	MSA	DLB	Reference
PEA	CSF	DNER	–	↓*	/	(102)
PEA		β-NGF	–	↓*	/	(102)
ELISA		NFL	–	↑*^†	/	(94)
		CRP	–	↑*	/
		SAA	–	↑*^†	/
		YKL-40	↓^†	↑*	/
Bead-based Luminex assays		C3	↑^†	↓*^†	/	(88)
Bead-based Luminex assays		CRP	–	↑*	/	(90)
		TNF-α	–	↑*	/
		IL-1β	–	↑*	/
		IL-6	–	↑*	/
ELISA	Brain in temporal cortex	ICAM-1	–	/	↑^†	(93)
	Brain in cingulate cortex	ICAM-1	–	/	↑^†
	Brain in cingulate cortex	CD-200	–	/	↓^†
Multiplex analysis	Serum	TNF-α	↑^†	–	/	(90)
		CCL2	↑^†	–	/
		CXCL10	↑^†	–	/
		CCL7	–	↓^†	/
		IL-17	–	↓^†	/
PCR		miR-30-5p	↑^†	↑*^†	/	(94)
PCR	Blood	P2Y6R	↑^†	↓*	/	(96)

*P < 0.05 versus PD.

^†P < 0.05 versus controls.