Table 1. Patient characteristics of the European and the non-European cohort, based on ICU mortality outcome.

Patient characteristics for the two other outcomes of interest, namely 30-day mortality and early identification of patients at low risk of deterioration are available in Tables A and B in S7 Text respectively.

ICU	European			non-European
Variables	Alive	Dead	p-value	Alive	Dead	p-value
Patients (%)	1574 (0.55)	1284 (0.45)	-	284 (0.46)	332 (0.54)	-
Age (year)	74 [72,78]	75 [72,79]	<0.001	75 [72,80]	77 [73,83]	0.003
Sex (Female)	477 (30.3)	350 (27.3)	0.081	115 (40.5)	129 (38.9)	0.74
Weight (kg)	80 [72,90]	80 [72,90]	0.313	78 [70,89]	78 [70,87]	0.621
Height (cm)	170 [165,178]	170 [165,177]	0.162	165 [159,170]	166 [160,173]	0.195
BMI	27.6 [24.8,30.9]	27.5 [24.7,30.8]	0.894	27.9 [24.9,33.2]	28.3 [25.6,31.1]	0.737
SOFA overall score	4 [3,7]	6 [4,9]	<0.001	4 [2,5]	7 [5,10]	<0.001
Presence of diabetes	490 (31.2)	462 (36.2)	0.006	156 (55.1)	187 (56.8)	0.73
Ischemic heart disease	318 (20.4)	308 (24.3)	0.015	78 (27.7)	92 (28.6)	0.875
Renal comorbidity	193 (12.3)	255 (20.0)	<0.001	29 (10.3)	80 (24.5)	<0.001
Arterial hypertension	1029 (65.6)	857 (66.9)	0.484	174 (61.5)	233 (71.3)	0.014
Pulmonary disease	341 (21.7)	301 (23.6)	0.241	47 (16.6)	59 (18.4)	0.642
Congestive heart failure	203 (13.0)	205 (16.2)	0.019	33 (11.8)	48 (14.8)	0.34
Mechanical ventilation	979 (62.2)	1142 (88.9)	<0.001	69 (24.3)	271 (81.6)	<0.001
Vasopressors	936 (59.5)	1146 (89.3)	<0.001	38 (13.4)	184 (55.4)	<0.001
Renal replacement therapy	150 (9.5)	317 (24.7)	<0.001	16 (5.6)	52 (15.7)	<0.001
Non-invasive ventilation	412 (26.2)	340 (26.5)	0.888	74 (26.1)	156 (47.0)	<0.001
Tracheostomy	350 (22.2)	241 (18.8)	0.026	15 (5.3)	13 (3.9)	0.537
ICU length of stay (day)	12 [6,26]	14 [7,22]	0.097	6 [3.8,10]	7 [4,11]	0.293