Figure 3.

Study design and body weight of App^NL-G-F and App^NL-F mice

(A and B) Schematic of the overall design of the study, with time points for treatments and analyses indicated. b.w., body weight; NOR, novel object recognition. The lengths of the time lines are not linear to the durations of intervals.

(C and D) B.w. of PBS or rh Bri2 BRICHOS R221E-treated App^NL-G-F and App^NL-F mice before each injection during the entire treatment periods. Data are represented as mean ± SEM. Multiple unpaired parametric t test was used to calculate p values for b.w. analysis. (A) and (B) were created using BioRender.