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. 2022 Dec 19;614(7948):521–529. doi: 10.1038/s41586-022-05644-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a-c, Average escape scores from DMS of epitope groups A (a), B (b), C (c) and each RBD residue. Scores are projected onto the structure of SARS-CoV-2 RBD (PDB: 6M0J). Average escape maps that indicate the score of each mutation from DMS on escape hotspots of antibodies, grouped by their sources, in epitope groups A (a), B (b) and C (c), and corresponding sequence alignment of SARS-CoV-2 WT and Omicron RBDs are also shown. The height of each amino acid in the escape maps represents its mutation escape score. Mutated sites in Omicron variants are marked in bold. d, Pseudovirus-neutralizing IC50 of antibodies in group A, B, and C, from wild-type vaccinated or convalescent individuals (WT-elicited, n = 133, 50, 106 for A-C, respectively), BA.1 (BA.1-elicited, n = 51, 49, 24), BA.2 (BA.2-elicited, n = 34, 36, 56) and BA.5 convalescent individuals (BA.5-elicited, n = 16, 6, 14). The geometric mean IC50s are labelled, and error bars indicate the geometric standard deviation. P-values are calculated using two-tailed Wilcoxon rank sum tests. *, p < 0.05; **, p < 0.01; ***, p < 0.001; NS, not significant, p > 0.05. All neutralization assays were conducted in at least two independent experiments.