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. 2022 Dec 19;614(7948):521–529. doi: 10.1038/s41586-022-05644-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Normalized average escape scores weighted by IC50 against D614G using DMS profiles of mAbs from ancestral strain infection or vaccination with a logo plot showing specific mutations on important residues. b, Normalized average escape scores of mAbs from BA.1 breakthrough infection, weighted by IC50 against BA.1. c, Normalized average escape scores of mAbs from ancestral strain infection or vaccination and BA.1 breakthrough infection, weighted by IC50 against BA.2. d, WT/BA.1/BA.2-elicited mAbs with IC50 against BA.2.75 and BA.5, similar to Fig. 4b. All neutralization assays were conducted in at least two independent experiments.