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. 2023 Feb 1;614(7948):548–554. doi: 10.1038/s41586-022-05672-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, Heatmap of 10 cellular neighbourhoods discovered in 416 lung adenocarcinoma patients. b, Representative images of 10 cellular neighbourhoods using Voronoi diagrams. c, Bubble plot where circle colour indicates which of the two comparisons on the y-axis has higher levels of the cell type on the x-axis (Female n = 233, Male n = 183), age (<75 yo n = 369, ≥75 yo n = 47), BMI (<30 n = 346, ≥30 n = 70), smoking status (Smoker n = 376, Non-smoker n = 38), pack-years (1—30 n = 89, ≥30 n = 256), stage (I-II n = 365, III-IV n = 50), progression status (Progression n = 64, No progression n = 340) and histological subgroup (Lepidic n = 40, Papillary n = 33, Acinar n = 190, Micropapillary n = 35, Solid n = 118). The size of the circle represents the level of significance. Survival^low refers to survival in the context of low (z score <0) prevalence of depicted 10 cellular neighbourhoods. The black boxes depict associations referenced in the text. For exact P values, see Supplementary Table 6. Statistical analysis (a: log-rank test, c: FDR-corrected two-tailed Student t-test for sex, age, BMI, smoking status, pack-years, stage, progression status; one-way ANOVA with Tukey multiple comparison test for histological subgroup; log-rank test for survival).